An Efficient Chitosan/Silica Composite Core–Shell Microspheres-Supported Pd Catalyst for Aryl Iodides Sonogashira Coupling Reactions
journal contributionposted on 07.12.2016 by Qing Cui, Hong Zhao, Guangsheng Luo, Jianhong Xu
Any type of content formally published in an academic journal, usually following a peer-review process.
Monodispersed chitosan/silica core–shell microspheres-supported Pd catalysts were prepared by a simple and affordable microfluidic device. Merely 5 mg of supported Pd catalyst (1 wt %) showed superior capability in Sonogashira coupling reactions between various aryl iodides and terminal alkynes in a mild environment (ligand-free, copper-free, amine-free, water–ethanol as solvent at 65 °C) even after eight cycles of use. These novel porous composite microspheres provide a new carrier to reduce the loading, enhance the activity, and increase the stability of noble metal catalyst.