An Efficient Approach to 3,4-Disubstituted Pyridin-2-ones. Formal Synthesis of Mappicine Ketone

Treatment of 3,4-dihydro-3-tosylpyridin-2-one 5 with sodium hydride and then alkyl halides gave various 3,4-disubstituted pyridin-2-ones 6. Formal synthesis of mappicine ketone (1) was also reported.