Alkyl Halides via Visible Light Mediated Dehalogenation

2019-11-14T14:41:25Z (GMT) by Manjula D. Rathnayake Jimmie D. Weaver
Net selective bromination and chlorination of activated C–H bonds can be effected in generally high yield via a simple perhalogenation/dehalogenation sequence. The photochemical reductions require no photocatalyst, relying instead on the formation of an electron donor–acceptor complex of the substrate and reductant, or alternatively autophotocatalysis. Some reactions proceed despite any apparent photon absorption, serving as a cautionary tale for other photochemical reactions involving amines. Mechanistic experiments provide an explanation for this observation.