ja6b12114_si_001.pdf (14.97 MB)
Alkali Metal-Hydroxide-Catalyzed C(sp)–H Bond silylation
journal contribution
posted on 2016-12-27, 00:00 authored by Anton
A. Toutov, Kerry N. Betz, David P. Schuman, Wen-Bo Liu, Alexey Fedorov, Brian M. Stoltz, Robert H. GrubbsDisclosed
is a mild, scalable, and chemoselective catalytic cross-dehydrogenative
C–H bond functionalization protocol for the construction of
C(sp)–Si bonds in a single step. The scope
of the alkyne and hydrosilane partners is substantial, providing an
entry point into various organosilane building blocks and additionally
enabling the discovery of a number of novel synthetic strategies.
Remarkably, the optimal catalysts are NaOH and KOH.