Aeruginosins 205A and -B, Serine Protease Inhibitory Glycopeptides from the Cyanobacterium Oscillatoria agardhii (NIES-205)
1997-03-21T00:00:00Z (GMT) by
Serine protease inhibitory glycopeptides, aeruginosins 205 A (1) and -B (2), were isolated from the cyanobacterium Oscillatoria agardhii (NIES-205). The gross structures of these glycopeptides were elucidated by mass and 2D NMR spectral data. The planar structure of 2 was the same as that of 1 but differed in the stereochemistries of 3-hydroxyleucine (Hleu) and phenyllactic acid 2-O-sulfate (Plas). These glycopeptides are potent inhibitors of trypsin and thrombin.
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