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Acylation of Alkenes with the Aid of AlCl3 and 2,6-Dibromopyridine

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posted on 2019-10-18, 14:08 authored by Shinya Tanaka, Tsukasa Kunisawa, Yuji Yoshii, Tetsutaro Hattori
Friedel–Crafts-type acylation of alkenes with acyl chlorides has been successfully conducted with a wide substrate scope by the combined use of AlCl3 and 2,6-dibromopyridine. Trisubstituted alkenes afford allylketones or vinylketones depending on the presence or absence of hydrogen atom(s) at the β-position to the acylation site, while monosubstituted alkenes exclusively afford vinylketones.

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