ol9b02688_si_001.pdf (16.06 MB)
Acylation of Alkenes with the Aid of AlCl3 and 2,6-Dibromopyridine
journal contribution
posted on 2019-10-18, 14:08 authored by Shinya Tanaka, Tsukasa Kunisawa, Yuji Yoshii, Tetsutaro HattoriFriedel–Crafts-type
acylation of alkenes with acyl chlorides
has been successfully conducted with a wide substrate scope by the
combined use of AlCl3 and 2,6-dibromopyridine. Trisubstituted
alkenes afford allylketones or vinylketones depending on the presence
or absence of hydrogen atom(s) at the β-position to the acylation
site, while monosubstituted alkenes exclusively afford vinylketones.