ol7b00769_si_002.cif (740 kB)
Acid-Mediated Intermolecular [3 + 2] Cycloaddition toward Pyrrolo[2,1‑a]isoquinolines: Total Synthesis of the Lamellarin Core and Lamellarin G Trimethyl Ether
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posted on 2017-04-19, 12:48 authored by Kai-Lu Zheng, Min-Qi You, Wen-Ming Shu, Yan-Dong Wu, An-Xin WuA novel one-pot reaction
has been developed for the efficient synthesis
of pyrrolo[2,1-a]isoquinolines and 1-dearyllamellarin
core from (E)-(2-nitrovinyl)benzenes and azomethine
ylides generated in situ. This strategy provides
a concise total synthesis of the lamellarin core and lamellarin G
trimethyl ether using electrophilic substitution and palladium-catalyzed
Suzuki–Miyaura cross-coupling reactions.
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Suzukinovel one-pot reactionlamellarin G trimethyl etherlamellarin corecross-couplingLamellarin Corepyrrolonitrovinylelectrophilic substitutionsynthesisAcid-MediatedLamellarin G Trimethyl Etherstrategy1- dearyllamellarin coreisoquinolinepalladium-catalyzedTotal SynthesisCycloadditionazomethine ylidesPyrroloIntermolecular
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