Acid-Mediated Intermolecular [3 + 2] Cycloaddition toward Pyrrolo[2,1‑a]isoquinolines: Total Synthesis of the Lamellarin Core and Lamellarin G Trimethyl Ether

A novel one-pot reaction has been developed for the efficient synthesis of pyrrolo­[2,1-a]­isoquinolines and 1-dearyllamellarin core from (E)-(2-nitrovinyl)­benzenes and azomethine ylides generated in situ. This strategy provides a concise total synthesis of the lamellarin core and lamellarin G trimethyl ether using electrophilic substitution and palladium-catalyzed Suzuki–Miyaura cross-coupling reactions.