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Acid-Controlled Access to β‑Sulfenyl Ketones and α,β-Disulfonyl Ketones by Pummerer Reaction of β‑Keto Sulfones and Sulfoxides

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posted on 2019-12-13, 21:44 authored by Jian Fan, Yiming Zhao, Jitan Zhang, Meihua Xie, Yuzhong Zhang
A convenient acid-mediated reaction of β-keto sulfones with sulfoxides under metal-free conditions has been developed, thereby delivering the acid-controlled synthesis of β-sulfenyl ketones and α,β-disulfonyl ketones in good to excellent yields. The mechanism of the transformations has been studied carefully, which suggested the involvement of a radical process in the formation of α,β-disulfonyl ketones.

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