Absolute Configuration Determination Using Enantiomeric Pairs of Molecularly Imprinted Polymers

2014-03-07T00:00:00Z (GMT) by Danielle S. Meador David A. Spivak
A new method for determination of absolute configuration (AC) is demonstrated using an enantiomeric pair of molecularly imprinted polymers, referred to as “DuoMIPs”. The ratio of HPLC capacity factors (<i>k</i>′) for the analyte on each of the DuoMIPs is defined as the γ factor and can be used to determine AC when above 1.2. A mnemonic based on the complementary binding geometry of the DuoMIPs was used to aid in understanding and prediction of AC.