A cis Amide Bond Surrogate Incorporating 1,2,4-Triazole

Hitotsuyanagi, Yukio; Motegi, Shuichi; Fukaya, Haruhiko; Takeya, Koichi

doi:10.1021/jo010904i.s002

jo010904i_si_002.pdf (119.85 kB)

A cis Amide Bond Surrogate Incorporating 1,2,4-Triazole

journal contribution

posted on 2002-04-17, 00:00 authored by Yukio Hitotsuyanagi, Shuichi Motegi, Haruhiko Fukaya, Koichi Takeya

A novel cis amide bond surrogate incorporating 1,2,4-triazole was designed and synthesized by the reaction of a thionotripeptide, formic hydrazide, and mercury(II) acetate. This method of surrogate formation was also applicable to a cyclic thionopeptide.