A Versatile Indium Trichloride Mediated
Prins-Type Reaction to Unsaturated
Heterocycles

Dobbs, Adrian P.; Guesné, Sebastien J. J.; Martinović, Saša; Coles, Simon J.; Hursthouse, Michael B.

doi:10.1021/jo034981k.s002

jo034981k_si_002.pdf (10.6 MB)

A Versatile Indium Trichloride Mediated Prins-Type Reaction to Unsaturated Heterocycles

journal contribution

posted on 2003-09-06, 00:00 authored by Adrian P. Dobbs, Sebastien J. J. Guesné, Saša Martinović, Simon J. Coles, Michael B. Hursthouse

A versatile and high-yielding indium trichloride mediated cyclization reaction of silylated homoallylic alcohols, thiols, or amines with aldehydes or epoxides is described as a rapid route to a range of unsaturated heterocycles. The excellent diastereoselectivity observed offers a method of wide scope and generality.