ol991188y_si_001.pdf (152.58 kB)
A Versatile Approach to PI(3,4)P2, PI(4,5)P2, and PI(3,4,5)P3 from l-(−)-Quebrachitol
journal contribution
posted on 1999-12-22, 00:00 authored by Lixin Qiao, Youhong Hu, Fajun Nan, Garth Powis, Alan P. KozikowskiA versatile synthesis of PI(3,4)P2, PI(4,5)P2, and PI(3,4,5)P3 is disclosed, starting from l-(−)-quebrachitol, a byproduct of latex production. The
crystalline nature of most intermediates and the utilization of inexpensive protecting groups facilitate this synthetic route and its scale-up.