ol0c00665_si_001.pdf (15.83 MB)
A Synthesis Strategy for the Production of a Macrolactone of Gulmirecin A via a Ni(0)-Mediated Reductive Cyclization Reaction
journal contribution
posted on 2020-03-12, 12:08 authored by Shun Kitahata, Akira Katsuyama, Satoshi IchikawaA synthesis strategy
for the production of a key synthetic intermediate
of gulmirecin A was described. The key reaction in the preparation
of the 12-membered macrolactone is the Ni(0)-mediated reductive cyclization
reaction of ynal using an N-heterocyclic carbene
ligand and silane reductant. In addition, the α-selective glycosylation
reaction of the macrolactone was performed to demonstrate the synthesis
of gulmirecin and disciformycin precursors.