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A Smart Fluorescent Probe for NO Detection and Application in Myocardial Fibrosis Imaging
journal contribution
posted on 2020-03-11, 17:46 authored by Tongliang Zhou, Junda Wang, Jiamin Xu, Cangxin Zheng, Yan Niu, Chao Wang, Fengrong Xu, Lan Yuan, Xin Zhao, Lei Liang, Ping XuOn
the basis of the pyridazinone scaffold and photoinduced electron
transfer (PET) mechanism, we designed a smart nitric oxide (NO) probe, PYSNO, with high sensitivity and selectivity. PYSNO exhibited a rapid response to both exogenous and endogenous NO.
This probe can also be used in tracking and investigating NO generation
in animal tissue. In the myocardial fibrosis model for mice, PYSNO exhibited a powerful imaging property in vivo as a result
of unravelling the progressive relationship between the generation
of myocardial NO and the occurrence of myocardial fibrosis.
