ol500402e_si_001.pdf (13.95 MB)
A Scalable and Regioselective Synthesis of 2‑Difluoromethyl Pyridines from Commodity Chemicals
journal contribution
posted on 2014-03-21, 00:00 authored by Jean-Nicolas Desrosiers, Christopher B. Kelly, Daniel R. Fandrick, Larry Nummy, Scot J. Campbell, Xudong Wei, Max Sarvestani, Heewon Lee, Alexander Sienkiewicz, Sanjit Sanyal, Xingzhong Zeng, Nelu Grinberg, Shengli Ma, Jinhua J. Song, Chris H. SenanayakeA scalable de novo synthesis of difluoromethyl
pyridines from inexpensive materials is reported. The pyridyl subunit
is built around the difluoromethyl group rather than a late stage
introduction of this moiety. This user-friendly approach allows access
to a diverse range of substitution patterns on all positions on the
ring system and on the difluoromethyl group.