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A Scalable and Regioselective Synthesis of 2‑Difluoromethyl Pyridines from Commodity Chemicals

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posted on 2014-03-21, 00:00 authored by Jean-Nicolas Desrosiers, Christopher B. Kelly, Daniel R. Fandrick, Larry Nummy, Scot J. Campbell, Xudong Wei, Max Sarvestani, Heewon Lee, Alexander Sienkiewicz, Sanjit Sanyal, Xingzhong Zeng, Nelu Grinberg, Shengli Ma, Jinhua J. Song, Chris H. Senanayake
A scalable de novo synthesis of difluoromethyl pyridines from inexpensive materials is reported. The pyridyl subunit is built around the difluoromethyl group rather than a late stage introduction of this moiety. This user-friendly approach allows access to a diverse range of substitution patterns on all positions on the ring system and on the difluoromethyl group.

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