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A Polyoxometalate Cluster Paradigm with Self-Adaptive Electronic Structure for Acidity/Reducibility-Specific Photothermal Conversion
journal contribution
posted on 2016-06-06, 00:00 authored by Chen Zhang, Wenbo Bu, Dalong Ni, Changjing Zuo, Chao Cheng, Qing Li, Linlin Zhang, Zheng Wang, Jianlin ShiPhotothermal conversion
is one of the most important keys in the
fields of solar collection, photo-hyperthermia, etc., and its performance
is highly dependent on the photothermal conversion materials used.
Especially in cancer photo-hyperthermia, the presently available small-molecule-
or nanomaterial-based agents still suffer from numerous drawbacks,
such as nonspecific accumulation and inevitable side effects on normal
tissues. Here we identify a Mo-based polyoxometalate cluster that
can change its dimension from small (1 nm) to big (tens of nanometer),
favoring its intratumoral accumulation, and enhance photothermal conversion
in response to the intratumoral acidity and reducibility, demonstrating
a previously unrealized tumor-specific photo-hyperthermia. Distinct
from the well-researched nano-based agents, a unique electronic structure
of this cluster has been identified as the origin of the observed
acidity-induced self-assembly and reduction-promoted NIR absorbance.
In addition to providing a promising clinical agent, this finding
is expected to establish a new physicochemical paradigm for photothermal
materials design based on clusters.