A Novel Enantioselective Synthetic
Route to Omuralide Analogues with the
Potential for Species Selectivity in
Proteasome Inhibition

Crane, Sheldon N.; Corey, E. J.

doi:10.1021/ol015757p.s001

ol015757p_si_001.pdf (62.72 kB)

A Novel Enantioselective Synthetic Route to Omuralide Analogues with the Potential for Species Selectivity in Proteasome Inhibition

journal contribution

posted on 2001-03-27, 00:00 authored by Sheldon N. Crane, E. J. Corey

The building blocks shown can be combined for an enantioselective construction of the simplified omuralide analogue 4 in nine steps, with the use of (R)-atrolactic acid as a recoverable chiral controller.

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Keywords

building blocks chiral controller Potential acid Species Selectivity atrolactic omuralide analogue 4 Novel Enantioselective Proteasome Inhibition enantioselective construction Omuralide Analogues

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CC BY-NC 4.0

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