ol7b03470_si_001.pdf (2.87 MB)
A Multicomponent Route to Functionalized Amides and Oxazolidinones
journal contribution
posted on 2017-12-01, 16:53 authored by Christopher G. McPherson, Alasdair K. Cooper, Andrius Bubliauskas, Paul Mulrainey, Craig Jamieson, Allan J. B. WatsonAn organobase-mediated multicomponent
reaction of unactivated esters,
epoxides, and amines is reported, furnishing functionalized amide
derivatives. A wide range of substrates are tolerated under the reaction
conditions, including chiral epoxides, which react with no erosion
of enantiopurity. Facile modification of the method through replacing
the ester derivative with dimethyl carbonate enables access to the
corresponding oxazolidinone derivatives.
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Facile modificationreaction conditionsoxazolidinone derivativeschiral epoxidesMulticomponent Routeaccessenantiopurityerosionmethodaminesorganobase-mediated multicomponent reactionunactivated estersOxazolidinonedimethyl carbonateFunctionalized Amidessubstratefurnishing functionalized amide derivatives
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