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A High-Fidelity Electrochemical Platform Based on Au–Se Interface for Biological Detection
journal contribution
posted on 2020-03-31, 20:44 authored by Yanzheng Chen, Xiaoting Song, Lu Li, Bo TangGold
(Au) electrodes are one of the most ideal electrodes and are
extensively used to construct electrochemical biological detection
platforms. The electrode–molecule interface between the Au
electrode and biomolecules is critical to the stability and efficiency
of the detection platform. However, traditional Au–sulfur (Au–S)
interfaces experience distortion due to high levels of glutathione
(GSH) and other biological thiols in biological samples as well as
a high charge barrier when electrons are injected into the biomolecule
from the Au electrode. In view of the higher bonding energy of Au–selenium
(Au–Se) bonds than those of Au–S bonds and the elevated
Fermi energy of the Au electrodes when Au–Se bonds are formed
instead of Au–S bonds at the interface between the electrodes
and molecules, we establish a new type of electrochemical platform
based on the Au–Se interface (Au–Se electrochemical
platform) for high-fidelity biological detection. Compared with that
of the electrochemical platform based on the Au–S interface
(Au–S electrochemical platform), the Au–Se electrochemical
platform shows a higher charge transfer rate and excellent stability
in millimolar levels of GSH. The Au–Se electrochemical platform
supplies an ideal solution for accurate biological detection and has
great potential in biomedical detection applications.