A General Method for the Formation of Aryl−Sulfur Bonds Using Copper(I) Catalysts
2002-07-12T00:00:00Z (GMT) by
We report a mild, palladium-free synthetic protocol for the cross-coupling reaction of aryl iodides and thiols using 10 mol % CuI and 10 mol % neocuproine, with NaOt-Bu as the base, in toluene at 110 °C. Using this protocol, we have shown that a variety of aryl sulfides can be synthesized in excellent yields from readily available iodides and thiols.
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