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A Diastereoselective Multicomponent Reaction for Construction of Alkynylamide-Substituted α,β-Diamino Acid Derivatives To Hunt Hits
dataset
posted on 2017-02-22, 00:00 authored by Ruirui Lei, Yong Wu, Suzhen Dong, Kaili Jia, Shunying Liu, Wenhao HuA highly diasetereoselective
Mannich-type multicomponent reaction
was developed to rapidly construct alkynylamide-substituted α,β-diamino
acid derivatives from simple starting materials under mild conditions
in moderate to good yields for hit hunting. Most of the resulting
products 4 exhibited good anticancer activity in HCT116,
BEL7402, and SMMC7721 cells.