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A Core/Satellite Multifunctional Nanotheranostic for in Vivo Imaging and Tumor Eradication by Radiation/Photothermal Synergistic Therapy
journal contribution
posted on 2016-02-18, 23:11 authored by Qingfeng Xiao, Xiangpeng Zheng, Wenbo Bu, Weiqiang Ge, Shengjian Zhang, Feng Chen, Huaiyong Xing, Qingguo Ren, Wenpei Fan, Kuaile Zhao, Yanqing Hua, Jianlin ShiTo integrate photothermal
ablation (PTA) with radiotherapy (RT)
for improved cancer therapy, we constructed a novel multifunctional
core/satellite nanotheranostic (CSNT) by decorating ultrasmall CuS
nanoparticles onto the surface of a silica-coated rare earth upconversion
nanoparticle. These CSNTs could not only convert near-infrared light
into heat for effective thermal ablation but also induce a highly
localized radiation dose boost to trigger substantially enhanced radiation
damage both in vitro and in vivo. With the synergistic interaction between PTA and the enhanced RT,
the tumor could be eradicated without visible recurrence in 120 days.
Notably, hematological analysis and histological examination unambiguously
revealed their negligible toxicity to the mice within a month. Moreover,
the novel CSNTs facilitate excellent upconversion luminescence/magnetic
resonance/computer tomography trimodal imagings. This multifunctional
nanocomposite is believed to be capable of playing a vital role in
future oncotherapy by the synergistic effects between enhanced RT
and PTA under the potential trimodal imaging guidance.
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Keywords
photothermal ablationVivo Imaginghistological examination120 daysRTradiation damagemultifunctional nanocompositePTAfuture oncotherapyhematological analysisdecorating ultrasmall CuS nanoparticlesTumor Eradicationradiation dosetrimodal imaging guidanceearth upconversion nanoparticlenovel CSNTscancer therapy
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