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A Catalytic Asymmetric Isatin-Involved Povarov Reaction: Diastereo- and Enantioselective Construction of Spiro[indolin-3,2′-quinoline] Scaffold

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journal contribution
posted on 2013-01-04, 00:00 authored by Feng Shi, Gui-Juan Xing, Ren-Yi Zhu, Wei Tan, Shujiang Tu
The first catalytic asymmetric isatin-involved Povarov reaction has been established. This method provides an unprecedented approach to access the enantioenriched spiro[indolin-3,2′-quinoline] scaffold with concomitant creation of two quaternary stereogenic centers in high yields and excellent stereoselectivities (all >99:1 dr's, up to 97% ee).

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