ol303154k_si_001.pdf (1.93 MB)
A Catalytic Asymmetric Isatin-Involved Povarov Reaction: Diastereo- and Enantioselective Construction of Spiro[indolin-3,2′-quinoline] Scaffold
journal contribution
posted on 2013-01-04, 00:00 authored by Feng Shi, Gui-Juan Xing, Ren-Yi Zhu, Wei Tan, Shujiang TuThe first catalytic asymmetric isatin-involved Povarov reaction has been established. This method provides an unprecedented approach to access the enantioenriched spiro[indolin-3,2′-quinoline] scaffold with concomitant creation of two quaternary stereogenic centers in high yields and excellent stereoselectivities (all >99:1 dr's, up to 97% ee).