id9b00190_si_001.pdf (8.51 MB)
A Bisphenolic Honokiol Analog Outcompetes Oral Antimicrobial Agent Cetylpyridinium Chloride via a Membrane-Associated Mechanism
journal contribution
posted on 2019-11-11, 22:15 authored by Cristian Ochoa, Amy E. Solinski, Marcus Nowlan, Madeline M. Dekarske, William M. Wuest, Marisa C. KozlowskiTargeting Streptococcus mutans is the primary focus in reducing dental
caries, one of the most common maladies in the world. Previously,
our groups discovered a potent bactericidal biaryl compound that was
inspired by the natural product honokiol. Herein, a structure activity
relationship (SAR) study to ascertain structural motifs key to inhibition
is outlined. Furthermore, mechanism studies show that bacterial membrane
disruption is central to the bacterial growth inhibition. During this
process, it was discovered that analog C2 demonstrated
a 4-fold better therapeutic index compared to the commercially available
antimicrobial cetylpyridinium chloride (CPC) making it a viable alternative
for oral care.
History
Usage metrics
Categories
Keywords
growth inhibitionMembrane-Associated Mechanism Targeting Streptococcus mutansmechanism studies showfocusHereinCPCbactericidal biaryl compoundalternativemembrane disruptionBisphenolic Honokiol Analog Outcompetes Oral Antimicrobial Agent Cetylpyridinium ChloridecariemotifSARmaladyanalog C 2worldstructure activity relationshipantimicrobial cetylpyridinium chlorideproduct honokiol4-
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC