AT-CuAAC
Synthesis of Mechanically Interlocked Oligonucleotides

Acevedo-Jake, Amanda; Ball, Andrew T.; Galli, Marzia; Kukwikila, Mikiembo; Denis, Mathieu; Singleton, Daniel G.; Tavassoli, Ali; Goldup, Stephen M.

doi:10.1021/jacs.0c01670.s001

ja0c01670_si_001.pdf (2.01 MB)

AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides

journal contribution

posted on 2020-03-20, 14:39 authored by Amanda Acevedo-Jake, Andrew T. Ball, Marzia Galli, Mikiembo Kukwikila, Mathieu Denis, Daniel G. Singleton, Ali Tavassoli, Stephen M. Goldup

We present a simple strategy for the synthesis of main chain oligonucleotide rotaxanes with precise control over the position of the macrocycle. The novel DNA-based rotaxanes were analyzed to assess the effect of the mechanical bond on their properties.