10.1021/acs.biomac.9b01128.s001
Tamiris Figueiredo
Tamiris
Figueiredo
Jing Jing
Jing
Jing
Isabelle Jeacomine
Isabelle
Jeacomine
Johan Olsson
Johan
Olsson
Thibaud Gerfaud
Thibaud
Gerfaud
Jean-Guy Boiteau
Jean-Guy
Boiteau
Claire Rome
Claire
Rome
Craig Harris
Craig
Harris
Rachel Auzély-Velty
Rachel
Auzély-Velty
Injectable Self-Healing Hydrogels Based on Boronate
Ester Formation between Hyaluronic Acid Partners Modified with Benzoxaborin
Derivatives and Saccharides
American Chemical Society
2019
fibroblast cells encapsulated
HA network
Injectable Self-Healing Hydrogels
benzoxaborin-saccharide complexation
injectability behaviors
ABORIN
Benzoxaborin Derivatives
Partners Modified
boronate ester cross-linked hydrogel
loss modulus
HA functionalized
-1-deoxy Dynamic rheological experiments
covalent hydrogels
pH
Boronate Ester Formation
boronic acid
storage modulus
frequency window
cross-linking method
7 days
gel-like behavior
2019-10-14 19:44:42
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Injectable_Self-Healing_Hydrogels_Based_on_Boronate_Ester_Formation_between_Hyaluronic_Acid_Partners_Modified_with_Benzoxaborin_Derivatives_and_Saccharides/9978587
We demonstrate here,
for the first time, formation of injectable
dynamic covalent hydrogels at physiological pH using benzoxaborin-saccharide
complexation as a reversible cross-linking method. The gels were prepared
by simply mixing hyaluronic acid modified with an original boronic
acid derivative, 3,4-dihydro-2<i>H</i>-benzo[<i>e</i>][1,2]oxaborinin-2-ol (1,2-ABORIN), and HA functionalized with 1-amino-1-deoxy-d-fructose. Dynamic rheological experiments confirmed the gel-like
behavior (storage modulus (<i>G</i>′) > loss modulus
(<i>G</i>″) in the frequency window explored) for
the designed HA-1,2-ABORIN/HA-fructose network. Furthermore, this
hydrogel exhibited excellent self-healing and injectability behaviors
in aqueous conditions and was found to be responsive to pH. Additionally,
fibroblast cells encapsulated in the HA network showed high viability
(>80% after 7 days of cell culture), as monitored by Live/Dead
staining.
Taken together, this new class of boronate ester cross-linked hydrogel
provides promising future for diverse biomedical applications.