Synthesis of Naphthols by Rh(III)-Catalyzed Domino
C–H Activation, Annulation, and Lactonization Using Sulfoxonium
Ylide as a Traceless Directing Group
Vinayak Hanchate
Anil Kumar
Kandikere Ramaiah Prabhu
10.1021/acs.orglett.9b03182.s001
https://acs.figshare.com/articles/journal_contribution/Synthesis_of_Naphthols_by_Rh_III_-Catalyzed_Domino_C_H_Activation_Annulation_and_Lactonization_Using_Sulfoxonium_Ylide_as_a_Traceless_Directing_Group/9959735
Sulfoxonium ylide
directed C–H activation catalyzed by the
Rh(III)-catalyst has been disclosed. In this study, sulfoxonium ylide
functions as a traceless directing group, which reacts with an unsymmetrical
alkyne, 4-hydroxy-2-alkynoate, to form the corresponding furanone-fused
1-naphthols. The application of the methodology has been illustrated
by synthesizing bromo lactones, which are used as an intermediate
in synthesizing photochromic dichroic materials. We have also demonstrated
the synthesis of an analogue of fimbricalyx lactone A.
2019-10-09 14:34:54
Annulation
sulfoxonium ylide functions
synthesizing photochromic dichroic materials
analogue
Rh
Sulfoxonium Ylide
application
Activation
4- hydroxy -2-alkynoate
methodology
activation
Synthesi
Lactonization
Naphthol
unsymmetrical alkyne
furanone-fused 1- naphthols
fimbricalyx lactone
traceles
Traceless Directing Group Sulfoxonium ylide
Domino
synthesizing bromo lactones
synthesis