10.1021/acsomega.9b02693.s004
Ciwang He
Ciwang
He
Ju Cai
Ju
Cai
Yang Zheng
Yang
Zheng
Chao Pei
Chao
Pei
Lihua Qiu
Lihua
Qiu
Xinfang Xu
Xinfang
Xu
Gold-Catalyzed Hydroalkoxylation/Povarov Reaction
Cascade of Alkynols with <i>N</i>‑Aryl Imines: Synthesis
of Tetrahydroquinolines
American Chemical Society
2019
aryl imines
stereoselectivity
series
Imine
Gold-Catalyzed
gold catalyst
access
substrate scope
Alkynol
Povarov reaction
intramolecular hydroalkoxylation
tricyclic tetrahydroquinolines
Synthesi
function
dihydrofuran species
Tetrahydroquinoline
material
alkynol
Cascade
formation
Aryl
gold-catalyzed
Hydroalkoxylation
cascade
one-pot
iminium
2019-09-09 18:12:31
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Gold-Catalyzed_Hydroalkoxylation_Povarov_Reaction_Cascade_of_Alkynols_with_i_N_i_Aryl_Imines_Synthesis_of_Tetrahydroquinolines/9788180
A one-pot gold-catalyzed hydroalkoxylation/Povarov
reaction cascade
of alkynols with <i>N</i>-aryl imines or in situ generated
iminium has been developed. The protocol provides a facile access
to a series of fused tricyclic tetrahydroquinolines with a broad substrate
scope using readily available materials under mild conditions. The
unique mechanistic feature is the dual function of the gold catalyst,
which first catalyzed the intramolecular hydroalkoxylation of alkynols,
and upon the formation of dihydrofuran species, promoted the following
Povarov reaction with high stereoselectivity.