10.1021/acsomega.9b02693.s004 Ciwang He Ciwang He Ju Cai Ju Cai Yang Zheng Yang Zheng Chao Pei Chao Pei Lihua Qiu Lihua Qiu Xinfang Xu Xinfang Xu Gold-Catalyzed Hydroalkoxylation/Povarov Reaction Cascade of Alkynols with <i>N</i>‑Aryl Imines: Synthesis of Tetrahydroquinolines American Chemical Society 2019 aryl imines stereoselectivity series Imine Gold-Catalyzed gold catalyst access substrate scope Alkynol Povarov reaction intramolecular hydroalkoxylation tricyclic tetrahydroquinolines Synthesi function dihydrofuran species Tetrahydroquinoline material alkynol Cascade formation Aryl gold-catalyzed Hydroalkoxylation cascade one-pot iminium 2019-09-09 18:12:31 Journal contribution https://acs.figshare.com/articles/journal_contribution/Gold-Catalyzed_Hydroalkoxylation_Povarov_Reaction_Cascade_of_Alkynols_with_i_N_i_Aryl_Imines_Synthesis_of_Tetrahydroquinolines/9788180 A one-pot gold-catalyzed hydroalkoxylation/Povarov reaction cascade of alkynols with <i>N</i>-aryl imines or in situ generated iminium has been developed. The protocol provides a facile access to a series of fused tricyclic tetrahydroquinolines with a broad substrate scope using readily available materials under mild conditions. The unique mechanistic feature is the dual function of the gold catalyst, which first catalyzed the intramolecular hydroalkoxylation of alkynols, and upon the formation of dihydrofuran species, promoted the following Povarov reaction with high stereoselectivity.