Hydrogen Sulfide Mediated Tandem Reaction of Selenenyl Sulfides and Its Application in Fluorescent Probe Development Yingying Wang Chun-tao Yang Shi Xu Wei Chen Ming Xian 10.1021/acs.orglett.9b02844.s001 https://acs.figshare.com/articles/journal_contribution/Hydrogen_Sulfide_Mediated_Tandem_Reaction_of_Selenenyl_Sulfides_and_Its_Application_in_Fluorescent_Probe_Development/9778409 A unique reaction between H<sub>2</sub>S and a selenenyl sulfide containing benzoate ester template was discovered. This reaction could be specifically triggered by H<sub>2</sub>S and lead to ester bond cleavage. The reaction was not affected by the presence of thiols such as glutathione and cysteine. With this reaction, a series of fluorescent probes were synthesized and evaluated. The probes exhibited high sensitivity/selectivity for H<sub>2</sub>S in both buffers and cells. 2019-09-06 12:38:52 probe selenenyl sulfide ester bond cleavage Hydrogen Sulfide Mediated Tandem Reaction benzoate ester template H 2 S Fluorescent Probe Development Selenenyl Sulfides