Hydrogen Sulfide Mediated Tandem Reaction of Selenenyl
Sulfides and Its Application in Fluorescent Probe Development
Yingying Wang
Chun-tao Yang
Shi Xu
Wei Chen
Ming Xian
10.1021/acs.orglett.9b02844.s001
https://acs.figshare.com/articles/journal_contribution/Hydrogen_Sulfide_Mediated_Tandem_Reaction_of_Selenenyl_Sulfides_and_Its_Application_in_Fluorescent_Probe_Development/9778409
A unique
reaction between H<sub>2</sub>S and a selenenyl sulfide containing
benzoate ester template was discovered. This reaction could be specifically
triggered by H<sub>2</sub>S and lead to ester bond cleavage. The reaction
was not affected by the presence of thiols such as glutathione and
cysteine. With this reaction, a series of fluorescent probes were
synthesized and evaluated. The probes exhibited high sensitivity/selectivity
for H<sub>2</sub>S in both buffers and cells.
2019-09-06 12:38:52
probe
selenenyl sulfide
ester bond cleavage
Hydrogen Sulfide Mediated Tandem Reaction
benzoate ester template
H 2 S
Fluorescent Probe Development
Selenenyl Sulfides