Li, Huaqiang Xu, Dan Sun, Weiguang Yang, Beiye Li, Fengli Liu, Mengting Wang, Jianping Xue, Yongbo Hu, Zhengxi Zhang, Yonghui HPLC-DAD-Directed Isolation of Linearly Fused Prenylated Indole Alkaloids from a Soil-Derived <i>Aspergillus versicolor</i> An HPLC-DAD-directed chemical investigation of the soil-derived fungus <i>Aspergillus versicolor</i> QC812 resulted in the isolation and identification of eight new linearly fused prenylated indole alkaloids, asperversiamides I–P (<b>1</b>–<b>8</b>), along with a congener, asperversiamide H (<b>9</b>). Their structures and absolute configurations were determined by spectroscopic analysis including HRESIMS and 1D and 2D NMR, electronic circular dichroism analysis, and single-crystal X-ray diffraction. Asperversiamide I (<b>1</b>), the first diketopiperazine derived from d-proline and l-tryptophan, possesses an unprecedented C-11-spiro-fused 6/6/5/5/6/5 hexacyclic ring system. Asperversiamide J (<b>2</b>) is the first linearly fused 6/6/5 tricyclic prenylated indole alkaloid to be reported. <b>1</b> and <b>2</b> showed moderate inhibitory activities against HeLa cells with IC<sub>50</sub> values of 7.3 and 6.4 μM, respectively. 7.3;single-crystal X-ray diffraction;l-tryptophan;-11-spiro;dichroism analysis;HPLC-DAD-directed chemical investigation;HPLC-DAD-Directed Isolation;prenylated indole alkaloids;soil-derived fungus Aspergillus versicolor QC 812;identification;Soil-Derived Aspergillus versicolor;IC 50 values;configuration;HeLa cells;2 D NMR;d-proline;congener;hexacyclic;asperversiamide H;diketopiperazine;1 D;isolation;tricyclic;6.4 μ M;spectroscopic analysis;Linearly Fused Prenylated Indole Alkaloids;HRESIMS;Asperversiamide J 2019-08-07
    https://acs.figshare.com/articles/dataset/HPLC-DAD-Directed_Isolation_of_Linearly_Fused_Prenylated_Indole_Alkaloids_from_a_Soil-Derived_i_Aspergillus_versicolor_i_/9336338
10.1021/acs.jnatprod.9b00183.s004