10.1021/jacs.9b05195.s001
Wei Chen
Wei
Chen
Chi-An Cheng
Chi-An
Cheng
Emily D. Cosco
Emily D.
Cosco
Shyam Ramakrishnan
Shyam
Ramakrishnan
Jakob G. P. Lingg
Jakob G. P.
Lingg
Oliver T. Bruns
Oliver T.
Bruns
Jeffrey I. Zink
Jeffrey I.
Zink
Ellen M. Sletten
Ellen M.
Sletten
Shortwave Infrared Imaging with J‑Aggregates
Stabilized in Hollow Mesoporous Silica Nanoparticles
American Chemical Society
2019
NIR fluorophore IR -140
PEGylated HMSNs
980 nm excitation
SWIR light
J-aggregate
SWIR imaging
mesoporous silica nanoparticles
resolution imaging
1000 nm
Hollow Mesoporous Silica Nanoparticles Tissue
red-shifted SWIR contrast agents
biocompatible contrast agents
2019-08-02 18:43:34
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Shortwave_Infrared_Imaging_with_J_Aggregates_Stabilized_in_Hollow_Mesoporous_Silica_Nanoparticles/9232589
Tissue
is translucent to shortwave infrared (SWIR) light, rendering
optical imaging superior in this region. However, the widespread use
of optical SWIR imaging has been limited, in part, by the lack of
bright, biocompatible contrast agents that absorb and emit light above
1000 nm. J-Aggregation offers a means to transform stable, near-infrared
(NIR) fluorophores into red-shifted SWIR contrast agents. Here we
demonstrate that J-aggregates of NIR fluorophore IR-140 can be prepared
inside hollow mesoporous silica nanoparticles (HMSNs) to result in
nanomaterials that absorb and emit SWIR light. The J-aggregates inside
PEGylated HMSNs are stable for multiple weeks in buffer and enable
high resolution imaging <i>in vivo</i> with 980 nm excitation.