Linear Peptides Containing d‑Leucine
with Neuroprotective Activities from the Leech <i>Whitmania pigra</i> Whitman
Zi-Yue Zhang
Nan Ma
Li-Jun Tao
Xue-Ying Gong
Wen-Cai Ye
Lei Wang
10.1021/acs.jnatprod.9b00322.s001
https://acs.figshare.com/articles/journal_contribution/Linear_Peptides_Containing_d_Leucine_with_Neuroprotective_Activities_from_the_Leech_i_Whitmania_pigra_i_Whitman/9176936
Three new linear peptides containing d-leucine, named
whitmantides A–C (<b>1</b>–<b>3</b>), were
isolated from the dried whole bodies of <i>Whitmania pigra</i> Whitman. Their structures with absolute configurations were elucidated
by Edman degradation, mass spectrometry, Marfey’s analysis,
and solid-phase synthesis. It is the first time that peptides containing d-amino acid in leeches were discovered. Compounds <b>1</b>–<b>3</b> displayed neuroprotective activities against
oxygen–glucose deprivation/reperfusion injury on Neuro-2a cells.
In addition, ex vivo serum stability tests showed that <b>1</b>–<b>3</b> were resistant to protease degradation.
2019-07-30 20:29:51
vivo serum stability tests
solid-phase synthesis
mass spectrometry
Neuroprotective Activities
Neuro -2a cells
d-leucine
Compound
injury
leech
peptide
whitmantide
Whitmania pigra Whitman
Linear Peptides Containing
Leech Whitmania pigra Whitman
d-amino acid
Marfey
configuration
analysis
neuroprotective activities
protease degradation
Edman degradation
deprivation