%0 Generic %A Hajra, Saumen %A Hazra, Atanu %A Saleh, SK Abu %D 2019 %T One-Pot Synthesis of Enantiopure Spiro[3,4-dihydrobenzo[b][1,4]oxazine-2,3′-oxindole] via Regio- and Stereoselective Tandem Ring Opening/Cyclization of Spiroaziridine Oxindoles with Bromophenols %U https://acs.figshare.com/articles/dataset/One-Pot_Synthesis_of_Enantiopure_Spiro_3_4-dihydrobenzo_i_b_i_1_4_oxazine-2_3_-oxindole_via_Regio-_and_Stereoselective_Tandem_Ring_Opening_Cyclization_of_Spiroaziridine_Oxindoles_with_Bromophenols/9170792 %R 10.1021/acs.joc.9b01611.s002 %2 https://acs.figshare.com/ndownloader/files/16709699 %K one-pot synthesis %K oxazine %K dihydrospiro %K tandem cyclization reaction %K 2- bromophenols %K Spiroaziridine Oxindoles %K Stereoselective Tandem Ring %K One-Pot Synthesis %K stereoselective spiroaziridine ring opening %X A highly efficient regio- and stereoselective spiroaziridine ring opening with 2-bromophenols and a subsequent tandem cyclization reaction was developed for the one-pot synthesis of enantiopure 3,4-dihydrospiro­[benzo­[b]­[1,4]­oxazine-2,3′-oxindole] with excellent enantiopurity (ee up to >99%). It is further extended to asymmetric synthesis of NH-free 3,4-dihydrospiro­[benzo­[b]­[1,4]­oxazine-2,3′-xindole] retaining the optical activity. %I ACS Publications