Yang, Beiye He, Yan Lin, Shuang Zhang, Jinwen Li, Huaqiang Wang, Jianping Hu, Zhengxi Zhang, Yonghui Antimicrobial Dolabellanes and Atranones from a Marine-Derived Strain of the Toxigenic Fungus <i>Stachybotrys chartarum</i> Three new dolabellane-type diterpenoids (<b>1</b>–<b>3</b>) and three new atranones (<b>4</b>–<b>6</b>) were isolated and identified from a marine-derived strain of the toxigenic fungus <i>Stachybotrys chartarum</i>. The planar and relative structures of <b>1</b>–<b>6</b> were elucidated using extensive spectroscopic methods, and their absolute configurations were fully confirmed via single-crystal X-ray diffraction analysis. Structurally, compounds <b>2</b> and <b>3</b> have a 1,14-<i>seco</i> dolabellane-type diterpenoid skeleton; compound <b>4</b> is the first C<sub>23</sub> atranone featuring a propan-2-one motif linked to a dolabellane-type diterpenoid by a carbon–carbon bond; compound <b>5</b> represents the first example of a C<sub>24</sub> atranone with a 2-methyltetrahydrofuran-3-carboxylate motif fused to a dolabellane-type diterpenoid at C-5–C-6. In an in vitro antimicrobial activity assay, compound <b>2</b> was active against <i>Acinetobacter baumannii</i> and <i>Enterococcus faecalis</i> with MIC values of 16 and 32 μg/mL, respectively, while compound <b>4</b> exhibited significant inhibitory activities against <i>Candida albicans</i>, <i>Enterococcus faecalis</i>, and methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) with MIC values of 8, 16, and 32 μg/mL, respectively. methicillin-resistant Staphylococcus aureus;compound 4;2- methyltetrahydrofuran -3-carboxylate motif;propan -2-one motif;antimicrobial activity assay;toxigenic fungus Stachybotrys chartarum;C 23 atranone;Toxigenic Fungus Stachybotrys chartarum;C 24 atranone;MRSA;Enterococcus faecalis;dolabellane-type diterpenoid;single-crystal X-ray diffraction analysis;MIC values 2019-07-02
    https://acs.figshare.com/articles/dataset/Antimicrobial_Dolabellanes_and_Atranones_from_a_Marine-Derived_Strain_of_the_Toxigenic_Fungus_i_Stachybotrys_chartarum_i_/8437010
10.1021/acs.jnatprod.9b00305.s006