%0 Generic %A Yang, Beiye %A He, Yan %A Lin, Shuang %A Zhang, Jinwen %A Li, Huaqiang %A Wang, Jianping %A Hu, Zhengxi %A Zhang, Yonghui %D 2019 %T Antimicrobial Dolabellanes and Atranones from a Marine-Derived Strain of the Toxigenic Fungus Stachybotrys chartarum %U https://acs.figshare.com/articles/dataset/Antimicrobial_Dolabellanes_and_Atranones_from_a_Marine-Derived_Strain_of_the_Toxigenic_Fungus_i_Stachybotrys_chartarum_i_/8437010 %R 10.1021/acs.jnatprod.9b00305.s006 %2 https://acs.figshare.com/ndownloader/files/15695666 %K methicillin-resistant Staphylococcus aureus %K compound 4 %K 2- methyltetrahydrofuran -3-carboxylate motif %K propan -2-one motif %K antimicrobial activity assay %K toxigenic fungus Stachybotrys chartarum %K C 23 atranone %K Toxigenic Fungus Stachybotrys chartarum %K C 24 atranone %K MRSA %K Enterococcus faecalis %K dolabellane-type diterpenoid %K single-crystal X-ray diffraction analysis %K MIC values %X Three new dolabellane-type diterpenoids (13) and three new atranones (46) were isolated and identified from a marine-derived strain of the toxigenic fungus Stachybotrys chartarum. The planar and relative structures of 16 were elucidated using extensive spectroscopic methods, and their absolute configurations were fully confirmed via single-crystal X-ray diffraction analysis. Structurally, compounds 2 and 3 have a 1,14-seco dolabellane-type diterpenoid skeleton; compound 4 is the first C23 atranone featuring a propan-2-one motif linked to a dolabellane-type diterpenoid by a carbon–carbon bond; compound 5 represents the first example of a C24 atranone with a 2-methyltetrahydrofuran-3-carboxylate motif fused to a dolabellane-type diterpenoid at C-5–C-6. In an in vitro antimicrobial activity assay, compound 2 was active against Acinetobacter baumannii and Enterococcus faecalis with MIC values of 16 and 32 μg/mL, respectively, while compound 4 exhibited significant inhibitory activities against Candida albicans, Enterococcus faecalis, and methicillin-resistant Staphylococcus aureus (MRSA) with MIC values of 8, 16, and 32 μg/mL, respectively. %I ACS Publications