%0 Generic
%A Yang, Beiye
%A He, Yan
%A Lin, Shuang
%A Zhang, Jinwen
%A Li, Huaqiang
%A Wang, Jianping
%A Hu, Zhengxi
%A Zhang, Yonghui
%D 2019
%T Antimicrobial Dolabellanes and Atranones from a Marine-Derived
Strain of the Toxigenic Fungus Stachybotrys chartarum
%U https://acs.figshare.com/articles/dataset/Antimicrobial_Dolabellanes_and_Atranones_from_a_Marine-Derived_Strain_of_the_Toxigenic_Fungus_i_Stachybotrys_chartarum_i_/8437010
%R 10.1021/acs.jnatprod.9b00305.s006
%2 https://acs.figshare.com/ndownloader/files/15695666
%K methicillin-resistant Staphylococcus aureus
%K compound 4
%K 2- methyltetrahydrofuran -3-carboxylate motif
%K propan -2-one motif
%K antimicrobial activity assay
%K toxigenic fungus Stachybotrys chartarum
%K C 23 atranone
%K Toxigenic Fungus Stachybotrys chartarum
%K C 24 atranone
%K MRSA
%K Enterococcus faecalis
%K dolabellane-type diterpenoid
%K single-crystal X-ray diffraction analysis
%K MIC values
%X Three new dolabellane-type diterpenoids
(1–3) and three new atranones (4–6) were isolated
and identified from a marine-derived strain of the toxigenic fungus Stachybotrys chartarum. The planar and relative structures
of 1–6 were elucidated using extensive
spectroscopic methods, and their absolute configurations were fully
confirmed via single-crystal X-ray diffraction analysis. Structurally,
compounds 2 and 3 have a 1,14-seco dolabellane-type diterpenoid skeleton; compound 4 is
the first C23 atranone featuring a propan-2-one motif linked
to a dolabellane-type diterpenoid by a carbon–carbon bond;
compound 5 represents the first example of a C24 atranone with a 2-methyltetrahydrofuran-3-carboxylate motif fused
to a dolabellane-type diterpenoid at C-5–C-6. In an in vitro
antimicrobial activity assay, compound 2 was active against Acinetobacter baumannii and Enterococcus faecalis with MIC values of 16 and 32 μg/mL, respectively, while compound 4 exhibited significant inhibitory activities against Candida albicans, Enterococcus faecalis, and methicillin-resistant Staphylococcus aureus (MRSA) with MIC values of 8, 16, and 32 μg/mL, respectively.
%I ACS Publications