Krasniqi, Besir Dehaen, Wim Synthesis of 1,2,3-Triazolo-Fused Allocolchicine Analogs via Intramolecular Oxidative Biaryl Coupling A novel series of 1,2,3-triazolo-fused allocolchicine analogs is described. The strategy to prepare these analogs involves two steps: The first step is the synthesis of 1,2,3-triazole derivatives using our previously reported triazolization method, and in the second step, cyclization between two aromatic rings occurs by using the combination of PIFA and BF<sub>3</sub>·Et<sub>2</sub>O as an oxidative coupling reagent. Furthermore, the diversity of aromatic rings and functional groups is explored in order to obtain seven- and eight-membered ring systems with medicinal chemistry interest. PIFA;Intramolecular Oxidative Biaryl;BF;analog;triazolization method;chemistry interest;eight-membered ring systems;novel series 2019-06-26
    https://acs.figshare.com/articles/journal_contribution/Synthesis_of_1_2_3-Triazolo-Fused_Allocolchicine_Analogs_via_Intramolecular_Oxidative_Biaryl_Coupling/8329694
10.1021/acs.orglett.9b01707.s001