Synthesis of Quinolines and Isoquinolines via Site-Selective, Domino Benzannulation of 2- and 3‑Chloropyridyl Ynones with Nitromethane BeesuMallesh MehtaGoverdhan 2019 An approach of general applicability to diverse quinolines and isoquinolines via a tactic that utilizes the recursive anion from nitromethane as a 1C-connector to stitch easily and appropriately crafted pyridyl ynones through a transition-metal-free, tandem Michael addition–S<sub>N</sub>Ar process is delineated. The straightforwardness, one-pot operation, and good yields mark this methodology for wider exploitation in targeting more embellished quinolines and isoquinolines and complex platforms embodying these moieties.