Tumor Reoxygenation and Blood Perfusion Enhanced Photodynamic
Therapy using Ultrathin Graphdiyne Oxide Nanosheets
Wei Jiang
Zhen Zhang
Qin Wang
Jiaxiang Dou
Yangyang Zhao
Yinchu Ma
Huarong Liu
Hangxun Xu
Yucai Wang
10.1021/acs.nanolett.9b01458.s001
https://acs.figshare.com/articles/journal_contribution/Tumor_Reoxygenation_and_Blood_Perfusion_Enhanced_Photodynamic_Therapy_using_Ultrathin_Graphdiyne_Oxide_Nanosheets/8209916
Both
diffusion-limited and perfusion-limited hypoxia are associated
with tumor progression, metastasis, and the resistance to therapeutic
modalities. A strategy that can efficiently overcome both types of
hypoxia to enhance the efficacy of cancer treatment has not been reported
yet. Here, it is shown that by using biomimetic ultrathin graphdiyne
oxide (GDYO) nanosheets, both types of hypoxia can be simultaneously
addressed toward an ideal photodynamic therapy (PDT). The GDYO nanosheets,
which are oxidized and exfoliated from graphdiyne (GDY), are able
to efficiently catalyze water oxidation to release O<sub>2</sub> and
generate singlet oxygen (<sup>1</sup>O<sub>2</sub>) using near-infrared
irradiation. Meanwhile, GDYO nanosheets also exhibit excellent light-to-heat
conversion performance with a photothermal conversion efficiency of
60.8%. Thus, after the GDYO nanosheets are coated with iRGD peptide-modified
red blood membrane (i-RBM) to achieve tumor targeting, the biomimetic
GDYO@i-RBM nanosheets can simultaneously enhance tumor reoxygenation
and blood perfusion for PDT. This study provides new insights into
utilizing novel water-splitting materials to relieve both diffusion-
and perfusion-limited hypoxia for the development of a novel therapeutic
platform.
2019-05-28 00:00:00
Blood Perfusion Enhanced Photodynamic Therapy
biomimetic ultrathin graphdiyne oxide
photothermal conversion efficiency
perfusion-limited hypoxia
catalyze water oxidation
tumor
Ultrathin Graphdiyne Oxide Nanosheets
type
PDT
1 O 2
release O 2
novel water-splitting materials
GDYO nanosheets
light-to-heat conversion performance