Highly Stable, Coordinated Polymeric Nanoparticles
Loading Copper(II) Diethyldithiocarbamate for Combinational Chemo/Chemodynamic
Therapy of Cancer
Xinyu Peng
Qingqing Pan
Boya Zhang
Shiyu Wan
Sai Li
Kui Luo
Yuji Pu
Bin He
10.1021/acs.biomac.9b00367.s001
https://acs.figshare.com/articles/journal_contribution/Highly_Stable_Coordinated_Polymeric_Nanoparticles_Loading_Copper_II_Diethyldithiocarbamate_for_Combinational_Chemo_Chemodynamic_Therapy_of_Cancer/8204150
Disulfiram (DSF)
has excellent <i>in vitro</i> anticancer
activity in the presence of Cu(II). The anticancer mechanism studies
have demonstrated that copper(II) diethyldithiocarbamate, Cu(DDC)<sub>2</sub>, is the crucial DSF’s metabolite exhibiting anticancer
activity. In this paper, highly stable polymeric nanoparticles were
fabricated via a coordination strategy between Cu(II) and carboxylic
groups in poly(ethylene glycol)-<i>b</i>-poly(ester-carbonate)
(PEC) for efficient loading of Cu(DDC)<sub>2</sub>, which was generated
by the <i>in situ</i> reaction of DSF and Cu(II). The properties
of nanoparticles such as drug loading contents, sizes, and morphologies
could be tuned by varying the feeding ratios of DSF, Cu(II), and PEC.
These Cu(II)/DDC-loaded nanoparticles showed excellent stability in
both neutral and weak acidic solutions and under dilution. <i>In vitro</i> anticancer study established that Cu(II)/DDC-loaded
nanoparticles could enable a combination therapy of Cu(DDC)<sub>2</sub>-based chemotherapy and chemodynamic therapy mediated by bioavailable
Cu(II) that was not in the form of Cu(DDC)<sub>2</sub>. The <i>in vivo</i> antitumor results demonstrated that the Cu(II)/DDC-loaded
nanoparticles showed superior antitumor efficacy to DSF/Cu(II). Our
study provided a facile and effective strategy of highly stable coordination-mediated
polymeric nanoparticles for combinational therapy of cancer.
2019-05-22 00:00:00
nanoparticle
anticancer activity
DSF
vivo antitumor results
PEC
Cu
anticancer mechanism studies
drug loading contents