%0 Journal Article %A Miao, Xuran %A Wen, Shengping %A Su, Yu %A Fu, Jiaju %A Luo, Xiaojun %A Wu, Ping %A Cai, Chenxin %A Jelinek, Raz %A Jiang, Li-Ping %A Zhu, Jun-Jie %D 2019 %T Graphene Quantum Dots Wrapped Gold Nanoparticles with Integrated Enhancement Mechanisms as Sensitive and Homogeneous Substrates for Surface-Enhanced Raman Spectroscopy %U https://acs.figshare.com/articles/journal_contribution/Graphene_Quantum_Dots_Wrapped_Gold_Nanoparticles_with_Integrated_Enhancement_Mechanisms_as_Sensitive_and_Homogeneous_Substrates_for_Surface-Enhanced_Raman_Spectroscopy/8134889 %R 10.1021/acs.analchem.9b01001.s001 %2 https://acs.figshare.com/ndownloader/files/15163064 %K MPBA %K glycan-overexpressed cancer cells %K Graphene Quantum Dots Wrapped Gold Nanoparticles %K detection %K Surface-Enhanced Raman Spectroscopy Rational engineering %K enhancement %K SERS %K imaging %K 4- mercaptophenylboronic acid %K as-prepared Au-NGQD NPs exhibit %K Raman-active nanostructured substrates %K surface-enhanced Raman spectroscopy %K NBT %K Au-NGQD NPs %K Integrated Enhancement Mechanisms %K N-doping graphene quantum dots %K Finite-difference time-domain simulations %K solution phase %X Rational engineering of highly stable and Raman-active nanostructured substrates is still urgently in demand for achieving sensitive and reliable surface-enhanced Raman spectroscopy (SERS) analysis in solution phase. Herein, monodisperse N-doping graphene quantum dots wrapped Au nanoparticles (Au-NGQD NPs) were facilely prepared, and further their applications as substrates in SERS-based detection and cellular imaging have been explored. The as-prepared Au-NGQD NPs exhibit superior long-term stability and biocompatibility, as well as large enhancement capability due to the integration of electromagnetic and chemical enhancements. The practical applicability of the Au-NGQD NPs was verified via the direct SERS tests of several kinds of aromatics in solution phase. Finite-difference time-domain simulations in combination with density functional theory calculation were also successfully used to explain the enhancement mechanism. Furthermore, the Au-NGQD NPs were conjugated with 4-nitrobenzenethiol (4-NBT, as reporter) and 4-mercaptophenylboronic acid (MPBA, as targeting element) to construct the MPBA/4-NBT@Au-NGQD probes, which could specifically recognize glycan-overexpressed cancer cells through SERS imaging on a cell surface. The prepared Au-NGQDs show great potential as superior SERS substrates in solution phase for on-site Raman detection. %I ACS Publications