Selective Antiproliferative Withanolides from Species
in the Genera <i>Eriolarynx</i> and <i>Deprea</i>
Sebastián
J. Castro
Carina N. Casero
José M. Padrón
Viviana E. Nicotra
10.1021/acs.jnatprod.9b00117.s001
https://acs.figshare.com/articles/journal_contribution/Selective_Antiproliferative_Withanolides_from_Species_in_the_Genera_i_Eriolarynx_i_and_i_Deprea_i_/8101175
Four new withanolides (<b>2</b>–<b>5</b>), together
with 4β,7β,20-trihydroxy-1-oxowitha-2,5,24-trienolide
(<b>1</b>), were isolated from the aerial parts of <i>Eriolarynx
iochromoides</i>. The antiproliferative activity of all compounds
purified from <i>E. iochromoides</i> together with four
withaphysalins and four physangulidines isolated previously from three <i>Deprea</i> species were evaluated against human solid tumor
cell lines. Four withanolides showed antiproliferative activity comparable
in potency to cisplatin. Selectivity toward cancer cells and interaction
with P-glycoprotein of the active withanolides were evaluated.
2019-05-09 00:00:00
Eriolarynx
iochromoide
tumor cell lines
withanolide
antiproliferative activity
Deprea
Selective Antiproliferative Withanolides