Selective Antiproliferative Withanolides from Species in the Genera <i>Eriolarynx</i> and <i>Deprea</i> Sebastián J. Castro Carina N. Casero José M. Padrón Viviana E. Nicotra 10.1021/acs.jnatprod.9b00117.s001 https://acs.figshare.com/articles/journal_contribution/Selective_Antiproliferative_Withanolides_from_Species_in_the_Genera_i_Eriolarynx_i_and_i_Deprea_i_/8101175 Four new withanolides (<b>2</b>–<b>5</b>), together with 4β,7β,20-trihydroxy-1-oxowitha-2,5,24-trienolide (<b>1</b>), were isolated from the aerial parts of <i>Eriolarynx iochromoides</i>. The antiproliferative activity of all compounds purified from <i>E. iochromoides</i> together with four withaphysalins and four physangulidines isolated previously from three <i>Deprea</i> species were evaluated against human solid tumor cell lines. Four withanolides showed antiproliferative activity comparable in potency to cisplatin. Selectivity toward cancer cells and interaction with P-glycoprotein of the active withanolides were evaluated. 2019-05-09 00:00:00 Eriolarynx iochromoide tumor cell lines withanolide antiproliferative activity Deprea Selective Antiproliferative Withanolides