10.1021/acsami.9b01615.s001
Huifang Shi
Huifang
Shi
Liang Zou
Liang
Zou
Kaiwei Huang
Kaiwei
Huang
He Wang
He
Wang
Chen Sun
Chen
Sun
Shan Wang
Shan
Wang
Huili Ma
Huili
Ma
Yarong He
Yarong
He
Jianpu Wang
Jianpu
Wang
Haidong Yu
Haidong
Yu
Wei Yao
Wei
Yao
Zhongfu An
Zhongfu
An
Qiang Zhao
Qiang
Zhao
Wei Huang
Wei
Huang
A
Highly Efficient Red Metal-free Organic Phosphor
for Time-Resolved Luminescence Imaging and Photodynamic Therapy
American Chemical Society
2019
particle size
design principle
phosphor
Efficient Red Metal-free Organic Phosphor
photodynamic anticancer therapy
Photodynamic Therapy
background fluorescence interference
application
metal-free RTP materials
Time-Resolved Luminescence Imaging
metal-free PNDs
5 nm
time-resolved luminescence imaging
2019-04-30 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/A_Highly_Efficient_Red_Metal-free_Organic_Phosphor_for_Time-Resolved_Luminescence_Imaging_and_Photodynamic_Therapy/8091113
Developing highly
efficient red metal-free organic phosphors for
biological applications is a formidable challenge. Here, we report
a novel molecular design principle to obtain red metal-free organic
phosphors with long emission lifetime (504.6 μs) and high phosphorescence
efficiency (14.6%) from the isolated molecules in the crystal. Furthermore,
the well-dispersed phosphorescent nanodots (PNDs) with the particle
size around 5 nm are prepared through polymer-encapsulation in an
aqueous solution, which show good biocompatibility and low cytotoxicity.
The metal-free PNDs are successfully applied to time-resolved luminescence
imaging to eliminate background fluorescence interference both in vitro
and vivo as well as effective photodynamic anticancer therapy for
the first time. This work will not only pave a pathway to develop
highly efficient metal-free RTP materials but also expand the scope
of their applications to biomedical fields.