Kono, Masato Harada, Shingo Nozaki, Tomoyuki Hashimoto, Yoshinori Murata, Shun-ichi Gröger, Harald Kuroda, Yusuke Yamada, Ken-ichi Takasu, Kiyosei Hamada, Yasumasa Nemoto, Tetsuhiro Asymmetric Formal Synthesis of (+)-Catharanthine via Desymmetrization of Isoquinuclidine Although (+)-catharanthine is an attractive alkaloid for both clinical research and organic synthetic chemistry, only a limited number of approaches for its catalytic asymmetric synthesis exist. Herein, we describe a novel strategy for synthesizing a chiral intermediate of (+)-catharanthine via phosphoric acid-catalyzed asymmetric desymmetrization of a <i>meso</i>-isoquinuclidine possessing a 1,3-diol unit that was synthesized by a formal amide insertion reaction. Desymmetrization;alkaloid;isoquinuclidine;research;synthesizing;novel strategy;desymmetrization;Catharanthine;approach;synthesis;Asymmetric Formal Synthesis;diol;catharanthine;meso;amide insertion reaction;chiral;Isoquinuclidine;Herein;phosphoric acid-catalyzed 2019-04-25
    https://acs.figshare.com/articles/journal_contribution/Asymmetric_Formal_Synthesis_of_-Catharanthine_via_Desymmetrization_of_Isoquinuclidine/8040872
10.1021/acs.orglett.9b01198.s001