%0 Journal Article %A Sukach, Volodymyr %A Melnykov, Serhii %A Bertho, Sylvain %A Diachenko, Iryna %A Retailleau, Pascal %A Vovk, Mykhailo %A Gillaizeau, Isabelle %D 2019 %T Access to Unprotected β‑Fluoroalkyl β‑Amino Acids and Their α‑Hydroxy Derivatives %U https://acs.figshare.com/articles/journal_contribution/Access_to_Unprotected_Fluoroalkyl_Amino_Acids_and_Their_Hydroxy_Derivatives/7850999 %R 10.1021/acs.orglett.9b00622.s001 %2 https://acs.figshare.com/ndownloader/files/14617190 %K reaction conditions %K β- %K α- hydroxy derivatives %K Access %K scalable manner %K NH-ketimine intermediates %K Derivative %K acid %K het %K decarboxylative Mannich-type reaction %K Fluoroalkyl %K building blocks %K protection %K Hydroxy %K ketone %K lithium hexamethyldisilazide %K preparation %K Unprotected %K Acid %K Amino %X Unprotected β-(het)­aryl-β-fluoroalkyl β-amino acids and their α-hydroxy derivatives can be readily obtained using a decarboxylative Mannich-type reaction without protection/deprotection steps. This protocol utilizes lithium hexamethyldisilazide and (het)­arylfluoroalkyl ketones to generate NH-ketimine intermediates. The mild reaction conditions allow the preparation of original fluorinated β-amino acids as useful building blocks in a practical and scalable manner. %I ACS Publications