10.1021/acsomega.9b00290.s002 Yicheng Chu Yicheng Chu Zhengfeng Xie Zhengfeng Xie Yuhua Yue Yuhua Yue Yongshuang Yue Yongshuang Yue Xiangjuan Kong Xiangjuan Kong Wei Shi Wei Shi Shun Feng Shun Feng New Fast, Highly Selective Probe with Both Aggregation-Induced Emission Enhancement and Intramolecular Charge-Transfer Characteristics for Homocysteine Detection American Chemical Society 2019 diphenylamino intramolecular charge transfer probe DBTC acid -4-carbaldehyde aggregation-induced emission enhancement performances 1 H NMR titration experiments Aggregation-Induced Emission Enhancement Hcy triazole Intramolecular Charge-Transfer Characteristics 2019-03-15 08:18:27 Dataset https://acs.figshare.com/articles/dataset/New_Fast_Highly_Selective_Probe_with_Both_Aggregation-Induced_Emission_Enhancement_and_Intramolecular_Charge-Transfer_Characteristics_for_Homocysteine_Detection/7850828 A new fluorescence probe 2-(4′-(diphenylamino)-[1,1-biphenyl]-4-yl)-2<i>H</i>-[1,2,3]-triazole-4-carbaldehyde (DBTC) was designed and synthesized through Suzuki coupling reaction between (4-(diphenylamino)­phenyl)­boronic acid and (4-bromophenyl)-2<i>H</i>-[1,2,3]-triazole-4-carbaldehyde. This probe DBTC had intramolecular charge transfer and aggregation-induced emission enhancement performances and showed high selectivity and sensitivity toward homocysteine (Hcy) in the presence of other amino acids. The detection limit of probe DBTC for Hcy was 3.05 × 10<sup>–6</sup> M, and the mechanism was researched by <sup>1</sup>H NMR titration experiments and mass spectrometry. Furthermore, cell-culture results indicated that probe DBTC was cell permeable and could be used to detect Hcy in living cells. The good characteristics of the probe DBTC had huge application potential use for researching the effects of Hcy in other biological systems.