%0 Generic %A Ji, Xingyue %A Pan, Zhixiang %A Li, Chunjie %A Kang, Ting %A De La Cruz, Ladie Kimberly C. %A Yang, Lingyun %A Yuan, Zhengnan %A Ke, Bowen %A Wang, Binghe %D 2019 %T Esterase-Sensitive and pH-Controlled Carbon Monoxide Prodrugs for Treating Systemic Inflammation %U https://acs.figshare.com/articles/dataset/Esterase-Sensitive_and_pH-Controlled_Carbon_Monoxide_Prodrugs_for_Treating_Systemic_Inflammation/7848155 %R 10.1021/acs.jmedchem.9b00073.s002 %2 https://acs.figshare.com/ndownloader/files/14611427 %K representative CO prodrug %K inflammation %K pH-Controlled Carbon Monoxide Prodrugs %K CO prodrugs %X A bottleneck for developing CO-based therapeutics is the lack of a safe and controllable delivery form. Herein, we describe efforts toward organic CO prodrugs with dual-responsive endogenous triggers. One representative CO prodrug showed significant anti-inflammatory effects both in vitro and in a LPS-simulated systemic inflammation model. These results firmly establish such CO prodrugs as either research tools or candidate compounds for the treatment of systemic inflammation or inflammation related organ injuries. %I ACS Publications