10.1021/acs.jmedchem.9b00073.s002 Xingyue Ji Xingyue Ji Zhixiang Pan Zhixiang Pan Chunjie Li Chunjie Li Ting Kang Ting Kang Ladie Kimberly C. De La Cruz Ladie Kimberly C. De La Cruz Lingyun Yang Lingyun Yang Zhengnan Yuan Zhengnan Yuan Bowen Ke Bowen Ke Binghe Wang Binghe Wang Esterase-Sensitive and pH-Controlled Carbon Monoxide Prodrugs for Treating Systemic Inflammation American Chemical Society 2019 representative CO prodrug inflammation pH-Controlled Carbon Monoxide Prodrugs CO prodrugs 2019-02-28 00:00:00 Dataset https://acs.figshare.com/articles/dataset/Esterase-Sensitive_and_pH-Controlled_Carbon_Monoxide_Prodrugs_for_Treating_Systemic_Inflammation/7848155 A bottleneck for developing CO-based therapeutics is the lack of a safe and controllable delivery form. Herein, we describe efforts toward organic CO prodrugs with dual-responsive endogenous triggers. One representative CO prodrug showed significant anti-inflammatory effects both in vitro and in a LPS-simulated systemic inflammation model. These results firmly establish such CO prodrugs as either research tools or candidate compounds for the treatment of systemic inflammation or inflammation related organ injuries.