10.1021/acs.jmedchem.9b00073.s002
Xingyue Ji
Xingyue
Ji
Zhixiang Pan
Zhixiang
Pan
Chunjie Li
Chunjie
Li
Ting Kang
Ting
Kang
Ladie Kimberly
C. De La Cruz
Ladie Kimberly
C.
De La Cruz
Lingyun Yang
Lingyun
Yang
Zhengnan Yuan
Zhengnan
Yuan
Bowen Ke
Bowen
Ke
Binghe Wang
Binghe
Wang
Esterase-Sensitive
and pH-Controlled Carbon Monoxide
Prodrugs for Treating Systemic Inflammation
American Chemical Society
2019
representative CO prodrug
inflammation
pH-Controlled Carbon Monoxide Prodrugs
CO prodrugs
2019-02-28 00:00:00
Dataset
https://acs.figshare.com/articles/dataset/Esterase-Sensitive_and_pH-Controlled_Carbon_Monoxide_Prodrugs_for_Treating_Systemic_Inflammation/7848155
A bottleneck
for developing CO-based therapeutics is the lack of
a safe and controllable delivery form. Herein, we describe efforts
toward organic CO prodrugs with dual-responsive endogenous triggers.
One representative CO prodrug showed significant anti-inflammatory
effects both in vitro and in a LPS-simulated systemic inflammation
model. These results firmly establish such CO prodrugs as either research
tools or candidate compounds for the treatment of systemic inflammation
or inflammation related organ injuries.