Ionic Cocrystals of Etiracetam and Levetiracetam: The Importance of Chirality for Ionic Cocrystals Lixing Song Oleksii Shemchuk Koen Robeyns Dario Braga Fabrizia Grepioni Tom Leyssens 10.1021/acs.cgd.9b00136.s001 https://acs.figshare.com/articles/journal_contribution/Ionic_Cocrystals_of_Etiracetam_and_Levetiracetam_The_Importance_of_Chirality_for_Ionic_Cocrystals/7836824 A striking variety of anhydrous and hydrated ionic cocrystals (ICCs) of the enantiopure antiepileptic drug (AED) levetiracetam and of its racemic intermediate etiracetam with the pharmaceutically acceptable salts CaCl<sub>2</sub> and MgCl<sub>2</sub> was synthesized and structurally characterized. The difference in the interaction of enantiopure and racemic compounds of interest with the inorganic salts was investigated. Variable-temperature X-ray powder diffraction (VT-XRPD) and calorimetric analyses (TGA and DSC) of all obtained ICCs showed a significant improvement in thermal stability with respect to pure racetams. 2019-03-04 00:00:00 salts CaCl 2 Variable-temperature X-ray powder diffraction Chirality stability AED Etiracetam racetam cocrystal Levetiracetam MgCl variety Importance enantiopure antiepileptic drug DSC racemic etiracetam levetiracetam VT-XRPD ICC pharmaceutically compound analyses TGA interaction Ionic Cocrystals