Ionic Cocrystals of Etiracetam and Levetiracetam:
The Importance of Chirality for Ionic Cocrystals
Lixing Song
Oleksii Shemchuk
Koen Robeyns
Dario Braga
Fabrizia Grepioni
Tom Leyssens
10.1021/acs.cgd.9b00136.s001
https://acs.figshare.com/articles/journal_contribution/Ionic_Cocrystals_of_Etiracetam_and_Levetiracetam_The_Importance_of_Chirality_for_Ionic_Cocrystals/7836824
A striking
variety of anhydrous and hydrated ionic cocrystals (ICCs) of the enantiopure
antiepileptic drug (AED) levetiracetam and of its racemic intermediate
etiracetam with the pharmaceutically acceptable salts CaCl<sub>2</sub> and MgCl<sub>2</sub> was synthesized and structurally characterized.
The difference in the interaction of enantiopure and racemic compounds
of interest with the inorganic salts was investigated. Variable-temperature
X-ray powder diffraction (VT-XRPD) and calorimetric analyses (TGA
and DSC) of all obtained ICCs showed a significant improvement in
thermal stability with respect to pure racetams.
2019-03-04 00:00:00
salts CaCl 2
Variable-temperature X-ray powder diffraction
Chirality
stability
AED
Etiracetam
racetam
cocrystal
Levetiracetam
MgCl
variety
Importance
enantiopure antiepileptic drug
DSC
racemic
etiracetam
levetiracetam
VT-XRPD
ICC
pharmaceutically
compound
analyses
TGA
interaction
Ionic Cocrystals