Azaphilone Alkaloids with Anti-inflammatory Activity from Fungus <i>Penicillium sclerotiorum</i> cib-411 Jia-Lin Tang Zong-Yuan Zhou Tao Yang Can Yao Lin-Wei Wu Guo-You Li 10.1021/acs.jafc.8b05628.s003 https://acs.figshare.com/articles/dataset/Azaphilone_Alkaloids_with_Anti-inflammatory_Activity_from_Fungus_i_Penicillium_sclerotiorum_i_cib-411/7722146 Nine new azaphilone alkaloids, penazaphilones A–I (<b>1</b>–<b>9</b>), were isolated from the solid fermented rice culture of <i>Penicillium sclerotiorum</i> cib-411. The structures of compounds <b>1</b>–<b>9</b> were elucidated based on HRESIMS, NMR, and CD spectroscopic data. The structures of <b>5</b> and <b>8</b> were confirmed by X-ray crystallographic analyses. Biological evaluation showed that compounds <b>1</b>, <b>5</b>, <b>6</b>, and <b>8</b> inhibited the production of nitric oxide (NO) on RAW 264.7 cells stimulated by lipopolysaccharide with IC<sub>50</sub> values of 15.29, 9.34, 9.50, and 7.05 μM, respectively. Meanwhile, they did not exhibit obvious cytotoxicity at a concentration of 50.0 μM. 2019-01-31 00:00:00 exhibit Fungus Penicillium sclerotiorum cib -411 nitric oxide concentration Penicillium sclerotiorum cib -411. azaphilone alkaloids 7.05 μ M rice culture IC 50 values Anti-inflammatory Activity X-ray 50.0 μ M compounds 1 penazaphilone Biological evaluation analyses RAW 264.7 cells Azaphilone Alkaloids cytotoxicity lipopolysaccharide NMR HRESIMS CD spectroscopic data