Azaphilone Alkaloids with Anti-inflammatory Activity
from Fungus <i>Penicillium sclerotiorum</i> cib-411
Jia-Lin Tang
Zong-Yuan Zhou
Tao Yang
Can Yao
Lin-Wei Wu
Guo-You Li
10.1021/acs.jafc.8b05628.s003
https://acs.figshare.com/articles/dataset/Azaphilone_Alkaloids_with_Anti-inflammatory_Activity_from_Fungus_i_Penicillium_sclerotiorum_i_cib-411/7722146
Nine new azaphilone alkaloids, penazaphilones
A–I (<b>1</b>–<b>9</b>), were isolated from
the solid fermented
rice culture of <i>Penicillium sclerotiorum</i> cib-411.
The structures of compounds <b>1</b>–<b>9</b> were
elucidated based on HRESIMS, NMR, and CD spectroscopic data. The structures
of <b>5</b> and <b>8</b> were confirmed by X-ray crystallographic
analyses. Biological evaluation showed that compounds <b>1</b>, <b>5</b>, <b>6</b>, and <b>8</b> inhibited the
production of nitric oxide (NO) on RAW 264.7 cells stimulated by lipopolysaccharide
with IC<sub>50</sub> values of 15.29, 9.34, 9.50, and 7.05 μM,
respectively. Meanwhile, they did not exhibit obvious cytotoxicity
at a concentration of 50.0 μM.
2019-01-31 00:00:00
exhibit
Fungus Penicillium sclerotiorum cib -411
nitric oxide
concentration
Penicillium sclerotiorum cib -411.
azaphilone alkaloids
7.05 μ M
rice culture
IC 50 values
Anti-inflammatory Activity
X-ray
50.0 μ M
compounds 1
penazaphilone
Biological evaluation
analyses
RAW 264.7 cells
Azaphilone Alkaloids
cytotoxicity
lipopolysaccharide
NMR
HRESIMS
CD spectroscopic data